STAT5a/PPARγ Pathway Regulates Involucrin Expression in Keratinocyte Differentiation
نویسندگان
چکیده
منابع مشابه
Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation.
Kazrin is an evolutionarily conserved protein that is upregulated during keratinocyte terminal differentiation. Kazrin localizes to desmosomes and binds the epidermal cornified envelope protein periplakin. Kazrin overexpression in human epidermal keratinocytes caused profound changes in cell shape, reduced filamentous actin, reorganized keratin filaments, and impaired assembly of intercellular ...
متن کاملDelta regulates keratinocyte spreading and motility independently of differentiation
In human interfollicular epidermis stem cells lie in clusters surrounded by their differentiated daughters, transit amplifying cells, an arrangement that reflects differences in cell cohesiveness and motility. Keratinocytes expressing a dominant negative Delta1 mutant, Delta(T), lacking most of the cytoplasmic domain, acquired the motile behaviour of transit cells while retaining their stem cel...
متن کاملCorrection: Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation
[This corrects the article DOI: 10.1371/journal.pone.0167392.].
متن کاملH19 lncRNA regulates keratinocyte differentiation by targeting miR-130b-3p
Aberrant differentiation of keratinocytes has been demonstrated to be associated with a number of skin diseases. A growing number of studies have showed that long noncoding RNAs (lncRNAs) have an important part in gene regulation, however, the role of lncRNAs in keratinocyte differentiation remains to be largely unknown. In the present study, we demonstrated that lncRNA-H19 act as an endogenous...
متن کاملForkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation
The epidermis serves as a critical protective barrier between the internal and external environment of the human body. Its remarkable barrier function is established through the keratinocyte (KC) terminal differentiation program. The transcription factors specifically regulating terminal differentiation remain largely unknown. Using a RNA-sequencing (RNA-seq) profiling approach, we found that f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2007
ISSN: 0022-202X
DOI: 10.1038/sj.jid.5700758